Preheat your oven to 375°F (190°C) and lightly grease a 9x13-inch baking dish.
Warm the corn tortillas in a dry skillet over medium heat for 10 to 15 seconds per side until pliable. Keep them wrapped in a clean kitchen towel to stay warm.
Spread a thin layer of mole sauce evenly across the bottom of the prepared baking dish.
Spoon about 1/4 cup of the shredded beef into the center of each warm tortilla, roll tightly, and place seam-side down in the baking dish.
Pour the remaining mole sauce evenly over the rolled enchiladas, ensuring the tortillas are fully coated to prevent drying out.
Bake uncovered for 15 to 20 minutes until the sauce is bubbling and the enchiladas are heated through.
Remove the baking dish from the oven. Immediately drizzle the top evenly with crema.
Sprinkle the queso fresco and toasted sesame seeds over the hot enchiladas.
Garnish with chopped fresh cilantro and sliced radishes. Serve immediately with lime wedges on the side.